THE KAM LAB

The Kam lab is focusing on neuronal and non-neuronal mechanisms of pathogenesis of neurodegenerative diseases including Alzheimer’s and Parkinson’s disease. We are trying to understand the molecular mechanisms of neuronal cell death as well as to identify the role of microglia-astrocyte axis in neurodegeneration. We are looking for identifying novel targets that are essential for pathogenesis of neurodegenerative diseases and developing disease-modifying drugs targeting key molecules.

Tae-In Kam, PhD

TITLE
Associate Professor of Neurology

EDUCATION
BS - Seoul National University, Seoul, Korea
PhD - Seoul National University, Seoul, Korea

RESEARCH FOCUS
Molecular mechanisms of neurodegeneration and neuroinflammation in neurodegenerative diseases.

RESEARCH TEAM

  • Jaejin Song, PhD

    POSTDOCTORAL FELLOW

  • YuRee Choi, PhD

    POSTDOCTORAL FELLOW

  • Jisu Shin, PhD

    POSTDOCTORAL FELLOW

SELECTED PUBLICATIONS

  • Park JS*, Kam TI*, Lee S, Park H, Oh Y, Kwon SH, Song JJ, Kim D, Kim H, Jhaldiyal A, Na DH, Lee KC, Park EJ, Pomper MG, Pletnikova O, Troncoso JC, Ko HS, Dawson VL, Dawson TM, Lee S. Blocking microglial activation of reactive astrocytes is neuroprotective in models of Alzheimer's disease. Acta Neuropathologica Communications 9(1), 78 (2021) (*equal contribution)

  • Kam TI*, Mao X*, Park H*, Chou SC, Karuppagounder SS, Umanah GE, Yun SP, Brahmarchari S, Panicker N, Chen R, Andrabi SA, Qi C, Poirier GG, Pletnikova O, Troncoso JC, Bekris LM, Leverenz JB, Pantelyat A, Ko HS, Rosenthal LS, Dawson TM, Dawson VL. Poly (ADP-ribose) drives pathologic a-synuclein neurodegeneration in Parkinson’s disease. Science 362(6414). pii: eaat8407 (2018) (*equal contribution)

  • Yun SP*, Kam TI*, Panicker N, Kim S, Oh Y, Park JS, Kwon SH, Park YJ, Karuppagounder SS, Park H, Kim S, Oh N, Kim NA, Lee S, Brahmachari S, Mao X, Lee JH, Kumar M, An D, Kang SU, Lee Y, Lee KC, Na DH, Kim D, Lee SH, Roschke V, Liddelow SA, Mari Z, Barres BA, Dawson VL, Lee S, Dawson TM, Ko HS. Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease. Nature Medicine 24(7), 931-938 (2018) (*equal contribution)

  • Gwon Y*, Kam TI*, Kim SH, Song S, Park H, Lim B, Lee H, Lee W, Jo DG, Jung YK. TOM1 regulates neuronal accumulation of amyloid-β oligomers by FcγRIIb2 variant in Alzheimer’s disease. Journal of Neuroscience pii:1996-17 (2018) (*equal contribution)

  • Kam TI*, Park H*, Gwon Y*, Song S, Kim SH, Moon SW, Jo DG, Jung YK. FcγRIIb-SHIP2 axis links Aβ to tau pathology by disrupting phosphoinositide metabolism in Alzheimer's disease model. Elife pii:e18691 (2016) (*equal contribution)  

  • Kam TI*, Song S*, Gwon Y, ParkH, Yan JJ, ImI, Choi JW, Choi TY, KimJ, SongDK, TakaiT, KimYC, Kim KS, Choi SY, Choi S, Klein WL, Yuan J, and Jung YK. FcγRIIb mediates amyloid-β neurotoxicity and memory impairment in Alzheimer’s disease. Journal of Clinical Investigation 123(7), 2791-2802 (2013) (*equal contribution)