THE KANG LAB

Kang's Lab aims to identify the key molecular hubs causing selective vulnerability in Parkinson's disease (PD) and Alzheimer's Disease (AD), which are crucial to identify discriminative markers for diagnosis and new treatment modalities. A hypothesis "Gut-Brain Axis" associated with DNA damages and Sleep disorders, known as a bidirectional complexity triggering the progressive neurodegenerations, has been tested using experimental data obtained from genetically associated transgenic mice as well as formidable data generated from human post-mortem tissues. To further provide a comprehensive perspective, we have been developing unique bioinformatic algorithms and building data structure for deep learning-based genomic data integration. State-of-the-art technologies incl. in-house developed single-cell genomics (HiF-snRNAseq; High Efficient single nuclei RNA sequencing), spatial genomics (10x Genomics), metagenomics (Illumina), and epigenomics including Cut&Tag, WGBS, ATAC-seq, Hi-C have been applied for data collection.

Sung-Ung Kang, Dr. Med. Sc.

TITLE
Assistant Professor of Neurology

EDUCATION
BS, MS - SungKyunKwan University, Korea
Dr. Med. Sc. - Medical University of Vienna, Austria

RESEARCH FOCUS
Neurodegenerative Diseases; Parkinson's Disease (PD); Alzheimer's Disease (AD); Gut-Brain Axis; Single-Cell Genomics; Epigenomics; Big Data; Deep Learning; Molecular Circadian Rhythms; Transgenic Animals; Identification of Cell-Type Specific Diagnostic Markers

RESEARCH TEAM

  • JiYang Song, PhD

    POSTDOCTORAL FELLOW

  • Fatih Akruti, MS

    SR RESEARCH SPECIALIST

  • Jinhee Park, PhD

    POSTDOCTORAL FELLOW

  • Heejin Jo, M.D.(KMD), PhD

    POSTDOCTORAL FELLOW

SELECTED PUBLICATIONS

  • Lee H, Lee JJ, Park NY, Dubey SK, Kim T, Ruan K, Lim SB, Park SH, Ha S, Kovlyagina I, Kim KT, Kim S, Oh Y, Kim H, Kang SU, Song MR, Lloyd TE, Maragakis NJ, Hong YB, Eoh H, Lee G. Multi-omic analysis of selectively vulnerable motor neuron subtypes implicates altered lipid metabolism in ALS. Nat Neurosci. 2021 Dec;24(12):1673-1685.

  • Seo BA, Kim D, Hwang H, Kim MS, Ma SX, Kwon SH, Kweon SH, Wang H, Yoo JM, Choi S, Kwon SH, Kang SU, Kam TI, Kim K, Karuppagounder SS, Kang BG, Lee S, Park H, Kim S, Yan W, Li YS, Kuo SH, Redding-Ochoa J, Pletnikova O, Troncoso JC, Lee G, Mao X, Dawson VL, Dawson TM, Ko HS.  TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson's disease. Neuron. 2021 Dec 1;109(23):3758-3774.e1

  • Yazar V, Kang SU, Ha S, Dawson VL, Dawson TM. Integrative genome-wide analysis of dopaminergic neuron-specific PARIS expression in Drosophila dissects recognition of multiple PPAR-γ associated gene regulation. Sci Rep. 2021 Nov 2;11(1):21500.

  • Jo A, Lee Y, Kam TI, Kang SU, Neifert S, Karuppagounder SS, Khang R, Kang H, Park H, Chou SC, Oh S, Jiang H, Swing DA, Ham S, Pirooznia S, Umanah GKE, Mao X, Kumar M, Ko HS, Kang HC, Lee BD, Lee YI, Andrabi SA, Park CH, Lee JY, Kim H, Kim H, Kim H, Cho JW, Paek SH, Na CH, Tessarollo L, Dawson VL, Dawson TM, Shin JH. PARIS farnesylation prevents neurodegeneration in models of Parkinson's disease. Sci Transl Med. 2021 Jul 28;13(604)

  • Lim SB,  Dawson VL,  Dawson TM,  Kang SU. ACE2-expressing endothelial cells in aging mouse brain. J Brain Res 2020;3:2.

  • Sharma A, Lee S, Kim H, Yoon H, Ha S, Kang SU. Molecular Crosstalk Between Circadian Rhythmicity and the Development of Neurodegenerative Disorders. Front Neurosci. 2020;14:844.

  • Pirooznia SK, Yuan C, Khan MR, Karuppagounder SS, Wang L, Xiong Y, Kang SU, Lee Y, Dawson VL, Dawson TM. PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiency. Mol Neurodegener. 2020 Mar 5;15(1):17.

  • Agarwal A, Park S, Ha S, Kwon JS, Khan MR, Kang BG, Dawson TM, Dawson VL, Andrabi SA, Kang SU.Quantitative mass spectrometric analysis of the mouse cerebral cortex after ischemic stroke. PLoS One. 2020;15(4):e0231978.

  • Kang SU, Park JT. Functional evaluation of alternative splicing in the FAM190A gene. Genes Genomics. 2019 Feb;41(2):193-199.

  • Moon HY, Javadi S, Stremlau M, Yoon KJ, Becker B, Kang SU, Zhao X, van Praag H. Conditioned media from AICAR-treated skeletal muscle cells increases neuronal differentiation of adult neural progenitor cells. Neuropharmacology. 2019 Feb;145(Pt A):123-130.